Ask a Dog Vet and Get Answers to Your Dog Veterinary Questions
Hello, this is Dr. KV. Welcome to JustAnswer. I am reviewing your question right now and will respond to you in just a moment...
Can you tell me a bit more...Is your dog taking any other medications right now?
I am concerned that he threw up and was shaking after taking the trazadone. Was this the first time he took this medication? How much did he have?
Thank you for the additional information. Trazadone is generally safe and well tolerated, it also has a very wide range, so some dogs do need to take a high dose. Based on your dog's size, it seems he is on a high dose right now. If you rather try an alternative medication, you can ask your vet about acepromazine and tramadol. Acepromazine is a tranquilizer, tramadol is a morphine-like medication. In my experience, this combination can be a good alternative to trazadone.
From a personal perspective, my own dog recently had TPLO surgery. I started him on trazadone, but later switched him to acepromazine and tramadol. He is a very active dog and the acepromazine kept him more comfortable.
It is a definite concern that he was vomiting and having tremors. It is difficult to say that those symptoms are related to the trazadone, as he was already on it for so many weeks, I would expect to see a reaction sooner. However, it is possible he is not tolerating the higher dose. I generally recommend 50 mg trazadone twice daily for a 25 pound dog, but higher doses can be given.
Acepromazine will provide sedation/tranquilization to get through 4 weeks. It can be given once or twice daily.
It is concerning that he has been vomiting and tremoring with the trazadone. If he were my patient, I would not continue this medication. If you prefer to stick with trazadone, you can try splitting up the dose over the day in 3 to 4 doses.
Alternatively, you can ask you vet about buprenorphine and tramadol which both provide sedation. Alprazolam (Xanax) is another option. Acepromazine is very commonly used for post-op orthopedic surgeries, travel, and occasional stressful events such as fireworks.