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The terminal plasma half-life is approximately 2 weeks in most dogs (meaning this is how long it takes to reach maximum effect and therefore double this number and this is how long it typically will last in the system); however, half-life of afoxolaner can differ between dogs (e.g. in one study, t1⁄2 in Collies at 25 mg/kg bodyweight was up to 47.7 days)This information is directly from their website based on their in house studiesPlease let me know how else I can assist you both today
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Unfortunately no. Besides increased water intake to flush it out and exercise to boost metabolism, this is one of the reasons I do not use the oral formulas for fleas and ticks (versus the topical which can be rinsed off)...
Milk thistle is used to help remove toxins from the liver but will not help detoxify in general