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Friend, one single dose of Lisinopril/HCTZ 10-12.25mg will Not be life-threatening or toxic to an 80 lbs Cheyenne, she may urinate more than usual and drink more than usual for today but otherwise will be fine. There should not be any negative interaction with the Apoquel or Levothyroxine, she will be fine. Just keep plenty of water available for her because of the diuretic effect of HCTZ.
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