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Hi. My nam is Dr. Bruce. I'm sorry to hear about this situation with Jasper. One of the more common side effects of doxycycline is stomach upset / vomiting. What I'd recommend here is calling your vet to let them know that he's having this stomach upset. They can then take the next needed step. They may reduce the dose for a few days to get him more used to it before increasing it. They may start him on a medication to help settle his stomach so he's less likely to be nauseated. Giving the medication with a meal can sometimes help them to be less nauseated too. Could the vomiting be due to something else? That is always a consideration as there is no specific way to know if it just being sensitive to the doxycycline.