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Hello. Thanks for the question.
16 mg of Nicotine is a pretty significant amount in a small dog like this. We can see vomiting, diarrhea, muscle tremors, salivation and excitation. I would treat fairly aggressively if it just happened within the last 2 hours.
First I would make her vomit. You could do this at home by giving 4 teaspoons of hydrogen peroxide orally. I would then take her to a vet to give activated charcoal and monitor her +/- keeping her on IV fluids to flush this out. Any signs are treated symptomatically with muscle relaxants, Atropine, ect.
If it's been > 4 hours and you're not seeing any signs, then she likely didn't get into any or her body is processing it without issues. When we see signs, it's pretty quick- usually within 1-2 hours.