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Is your dog's prostate enlarged? is he having trouble urinating because of it?
Neutering is the best way to reduce an enlarged prostate. There are medications that can be given which can help by blocking the hormones that cause prostate enlargement (mainly testosterone) but these are by far less effective than eliminating the source of those hormones all together (by removing the testicles). Prostatic infections can be hard to treat and may require surgery or long term antibiotics and an enlarged prostate can prevent a dog from being able to urinate normally which can be a life threatening situation. Interestingly enough, dogs and humans are both affected by a condition called benign prostatic hyperplasia due to testosterone's effects on the prostate in these species where as in most other species this condition is rare. Prostatic cysts or other abnormalities may require more invasive management than simply neutering but this can help.