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While both of these medicines are rather safe in most cases, the Benadryl dose is a significantly higher dose than is typically used in a dog of Chopper's weight. As a result, I'd consider the safest approach to be to try to have Chopper vomit up the medications. This is best done in the veterinary clinic with an injection of Apomorphine, however, if veterinary care is not available, Hydrogen Peroxide 3% can be given orally to induce vomiting at home. A dog of Chopper's weight would typically be given 20-25mL of peroxide, which is about 1-1/2 tablespoons. Typically, vomiting occurs within about 10 minutes.