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Ask Dr. Michael Salkin Your Own Question
Dr. Michael Salkin
Dr. Michael Salkin, Veterinarian
Category: Dog Veterinary
Satisfied Customers: 23806
Experience:  University of California at Davis graduate veterinarian with 44 years of experience
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Our dog may have swallowed one olanzapine 10 mg pill -

Customer Question

hi: our dog may have swallowed one olanzapine 10 mg pill - He is 50 lbs. Is there any danger?
Submitted: 5 months ago.
Category: Dog Veterinary
Expert:  Dr. Michael Salkin replied 5 months ago.
Not a significant danger...10 mg/22.7 kg (50 lbs) = 0.44 mg/kg. In acute single dose studies, doses of 25-100 mg/kg didn't cause death. A dose related central nervous system depression lasting between 3-5 days was noted, however. Ataxia ("drunken sailor"), lassitude (sedation, lethargy), tremor, increased heart rate, labored respiration, and miosis (small than normal pupils) were noted at higher doses. I would expect Macree to do well ingesting such a small dose for his size. I wouldn't induce emesis or treat in any manner. I regret that I don't see any information concerning the half-life of this drug in dogs. It's quite long in humans, however - a little over a day.Please respond with further questions or concerns if you wish.

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