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Ask Dr. Michael Salkin Your Own Question
Dr. Michael Salkin
Dr. Michael Salkin, Veterinarian
Category: Dog Veterinary
Satisfied Customers: 24467
Experience:  University of California at Davis graduate veterinarian with 44 years of experience
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My dog occasionally takes Doxepin seasonal

Customer Question

Hello- My dog occasionally takes Doxepin for her seasonal allergies. I read somewhere on line that Doxepin is contraindicated with flea and tick collars such as Preventic. It is also contraindicated with Proin. Do you have any more information related to these contraindications. And is Doxepin ALSO contraindicated with Frontline and other top spot flea and tick applications
Submitted: 7 months ago.
Category: Dog Veterinary
Expert:  Dr. Michael Salkin replied 7 months ago.
Yes, Preventic collars as well as Mitaban dip contain amitraz which is a monoamine oxidase inhibitor. Doxepin is a tricyclic antidepressant/antihistamine. Concomitant use (within 14 days) of tricyclics with monoamine oxidase inhibitors is generally contraindicated (serotonin syndrome). Here's a synopsis of that syndrome for you: https://www.nlm.nih.gov/medlineplus/ency/article/007272.htmTricyclic antidepressants such as Doxepin shouldn't be administered concomitantly with phenylpropanolamine (Proin) due to an increased chance of hypertension. I'm not aware of any other flea or tick products containing a monoamine oxidase inhibitor.Please respond with further questions or concerns if you wish. I have to leave my computer for an hour but I promise to reply as soon as I return if need be.