Thanks for the information. It sounds like there is still an underlying medical issue that needs to be uncovered. The problem is that she will need to have more testing ran. From what you are describing and her response to prednisone, my first thought is that she has an issue with inflammatory bowel disease (IBD). I would also want to rule out pancreatitis
, pancreatic insufficiency, small intestinal bacterial overgrowth (SIBO), a long standing GI infection (i.e.; bacterial, protozoal, fungal), adrenal gland insufficiency or potential gastrointestinal lymphoma
. First and foremost, I would recommend an abdominal ultrasound to evaluate all the organs better but more specifically evaluate the lining of the intestinal tract. I would want to know if it is thickened and if there are any enlarged lymph nodes in the area. If thickened, then IBD and lymphoma need to be ruled out. Unfortunately, a biopsy of the intestinal tract is needed for a definitive diagnosis. With IBD, though, she will most likely need to stay on prednisone or some other immune system modulating drug and a hypoallergenic diet
long term. I would also run a GI blood panel on her. Check her pancreatic lipase, TLI (for pancreatic insufficiency) and her serum cobalamin/folate (for SIBO). Many of these guys are deficient in cobalamin, which is necessary for absorption and intestinal cell health. I would consider a fecal culture as well, but it wouldn't be the first thing I do if going in a step wise progression. I would also consider doing a coritsol screen to see if she may have adrenal insufficiency. That could cause chronic gastrointestinal problems and will response to prednisone. I hope this is the information you are looking for. If not, please let me know. My goal is to make sure that you get all your question answered and all the information you need. If you are satisfied with my answer, PLEASE RATE IT. Rating it is the only way I get credit for helping you. If you feel like it is not helpful to you, or if there is more information you need, please respond back to me before rating. Realize that our conversation is not intended to diagnose or treat a condition. There has to be a valid veterinary-client-patient relationship established with an exam, according to law. You should always follow up with your vet.