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Hi, this is Dr. Gabby.
Yes, dogs can take D-mannose.
Usually 76mg per 20 pounds of dog every 12-24 hours.
If he is drinking more water, the infection may have progressed into his kidneys.
So if at all possible I would try to get him to a vet tonight or tomorrow.
The sooner the better.
Does that help? Do you have any additional questions?