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Hello - I am Dr. Matt - I would be glad to help you with your question.
Just to clarify - did you give the medication 12.5 mg of doxylamine succinate or doxycycline to your maltese?
What medication do you normally give to him for car rides?
Thank you for the additional information.
I have good news for you! Doxylamine succinate is not commonly used in dogs though this medication is safe at a dose of 4-6mg/kg or 2-3 mg per pound. This means that a dose of 1 mg per pound is well below the normal dose and is incredibly safe. I honestly would not have expected him to have any side effects. This medication can be given 3-4 times a day in dogs therefore should be out of his system after 6-8 hours at the longest. Rest easy tonight - you did not harm him at all.
Hope this helps - please feel free to reply if needed. Thank you for the question!