Ask a Dog Vet and Get Answers to Your Dog Veterinary Questions
I am sorry to hear about Ava's problems, and that leukemia is suspected. My name is Rebecca. I am a veterinarian and will do my best to help.
Deramaxx and prednisone do not normally cause the white blood cell count to go up. Since both are anti inflammatory, they tend to make white counts go down. I have never seen a white count as high as 100.0 caused by these medications.
Is she spayed? I have seen a white count that high in unspayed females with infections of the uterus.
Leukemia is cancer of the white blood cells. A definitive diagnosis usually means a bone marrow biopsy. It would help to see her blood count reports and see which of her white cells are elevated: lymphocytes, or neutrophils, or eosinophils. Sometimes we can get a definitive diagnosis of leukemia by having a "clinical pathology review" of the blood cells. Your vet can request the lab they use have a pathologist look at Ava's blood cells under a microscope and see if any of them look abnormal enough to suspect leukemia.
Please let me know what other questions I can answer.
I hope you were able to see what I wrote! Let me know how she is doing, if this was helpful, and if you have any more questions.