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Hello, this is Dr. Jess. I am sorry to hear about your Rotty! Can you tell me, does his belly look bloated at all? One thing I worry about in a large dog who is panting excessively and can't seem to settle/lay down and get comfortable is bloating. Do you feel like his belly looks at all distended?
Ok, that is good! Panting for an extended period of time is of concern though, and shouldn't be ignored. If this happened after your dog had been outside of very active, you can try putting him in a cool area of the house with a fan on him for a little while and see if he improved.
Panting can be seen with pain, so it is possible he is having some discomfort somewhere in his body. This can be hard to determine because some dogs are very stoic and won't necessarily cry out when you touch them. Panting can also be a sign of respiratory disease,so if he starts again, then a vet exam is in order! good luck!