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Hello. thanks for the question.
Nuroplex is a combination of many different herbal ingredients. There are no safety studies done in dogs, so we don't know if it's harmful on the kidneys or liver. It appears safe, but we just don't have the tox studies to back that up. We also don't have any therapeutic studies, so we don't know if it's actually helping or not. There are many products like this out there. My general feeling is that they may help and shouldn't hurt.
When it comes to the seizures, I would continue Phenobarbital and make sure blood levels are checked periodically. If we're having breakthrough seizures more than once a month, then the dose should be increased. If we're having these breakthrough seizures and the blood levels are at the high end of the therapeutic range, then I'd add Zonisamide or Keppra. If the liver function is declining due to Phenobarbital, then again I'd add one of those other meds or switch completely if needed. Those two (Zonisamide and Keppra) are much easier on the kidneys and liver than Phenobarb.
I hope this helps, let me know if you have any other questions.