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Good Morning and welcome! I am Dr. Loretta, a licensed veterinarian and I am happy to answer your question.
There are couple things that this can be and your vet will have to biopsy this area to know for sure. One is an Autoimmune condition called Lupus which will respond to steroid treatments. The other is a condition called Collie Nose or Nasal Solar Dermatitis that is caused by a photosensitization and will require sunblock. These are not serious but uncomfortable.here is a LINK that explains in more detail.
It would be best, ***** ***** biopsy has not been done on Tug, that this be performed to know for sure how best to treat Tug. He could be coming resistant to the medication but your vet needs to find the cause for this in order to find the correct treatment for his condition.
Does that make sense to you?
Please let me know if you have ANY other questions. My goal is to give you 100% satisfaction and if you are not yet satisfied, please REPLY so I can clarify for you.Sincerely, ***** *****
This could be any of the conditions that causes this cracking nose syndrome. I wish I could be more specific but if the prednisone did not cure it and the biopsy was inconclusive, seems like it is another issue. I know this is hard on you but it also may be a genetic defect that you can only manage but never cure. Probably continue with the Synotic if that is helping or a cortisone creme but, as you know, often this causes them to lick more. So sorry that I could not be more help for your poor sweet Tug....
Sincerely. Dr. Loretta