Thank you again.
Now this is a drug used in dogs via injection on rare occasion, so its not an outright poisoning and we do have an idea of risks associated with this drug in dogs. Specifically it carries the risk of GI upset, gastritis, liver and kidney damage, and clotting issues.
Now considering the dose, none of these are overdoses for the injectable version. Still since we don't use this orally in dogs, we cannot assume that it will do no harm given this way. Therefore, the best option would be to err on the side of caution here for your dogs.
Since this was given orally so recently, there are some steps we can start now to help limit the risk here. To start, we can induce vomiting. To induce vomiting at home, you can administer 3% hydrogen peroxide orally at a dose of 1ml per pound. (2 teaspoons per 10 pounds of body weight). You can give it via dropper, syringe, turkey baster – we just want to get it in. After giving this orally, move each dog’s abdomen around or get them walking about to get things mixing. This should usually lead to vomiting. If it is unsuccessful after 10 minutes then it can be repeated twice more. And if we still have no vomiting, then you'd need to consider seeing your local vet (or ER vet) so that apomorhpine (a very strong injectable emetic) can be administered just get this out of the stomach and avoid any adverse issues.
As well or alternatively, you can also use activated charcoal at this stage. This is available over the counter from the pharmacy (ask for the high strength version in grams, not the one for gas since you will need a lot of these) and works by binding any remaining material in the stomach. For activated charcoal, we tend to give 1-4 grams per pound every 8 hrs. This can be mixed with food to be fed or with water to syringe feed (do note that it stains, so keep it away from white carpets/clothes). This will just limit how much is absorbed and reduce the intoxication risk here.
Finally, after the above, we do want to try to address any potential GI upset here for the next 24-48 hours. To do so, plan to offer a light diet option for a few days. Examples of an easily digestible diet include cooked white rice with boiled chicken, boiled white fish, scrambled egg, or meat baby food (as long as its free from garlic or onion powder). Ideally, we want to offer this as small frequent meals to keep the stomach settled. As well, if any dog shows nausea, then we can also use an antacid like Pepcid (More Info/Dose @ http://www.petplace.com/article/drug-library/library/over-the-counter/famotidine-pepcid) or Zantac (More Info/Dose @ http://www.petplace.com/article/drug-library/library/over-the-counter/ranitidine-hcl-zantac). These are usually given 20 minutes before offering food to allow absorption and of course you want to double check with your vet before use if anyone has known health issues or is on any medications you haven't mentioned.
Just in case you need a local emergency vet, you can check @ http://www.vetlocator.com/ or via
Overall, this is thankfully not an overdose but it has been given in a way that we do not have safety margins for dogs. Therefore, there is some risk here and if they had this 20 minutes ago, then the above steps would be best to get it out of their system and limit any harm from this. Of course, any of those signs I noted and we'd need them seen urgently for fluids and treatment to counter this further.
Please take care,
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