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Hello, this is Dr. Jess. I am very sorry to hear about your dog. Given her history of heart issues and the description of her current condition, I am very worried she could be in congestive heart failure and she is suffering from pulmonary edema (fluid build up in her lungs as a result of the heart failure). This is an emergency situation and you should not delay in getting her into a vet's office, if your vet is open, then you need to find an emergency vet to take her in to see. Any time a pet has labored breathing it is an emergency. It is possible your dog may improve with IV lasix therapy and oxygen, but if you do not get her in ASAP, she could decline rapidly.
Here is an article on CHF (congestive heart failure). As you can see, trouble breathing, coughing, and weight loss are signs of this disease. http://pets.webmd.com/dogs/congestive-heart-failure-dogs