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I am sorry to hear she has a pyometra.
I have personally not had much luck with the prostaglandin/antibiotic treatment. I have read that it can work, but it is not 100%. And, the next time she goes into heat she is likely to get pyometra again even if it does work this time.
I usually give the prostaglandins a few days or so and then Xray or ultrasound the uterus. If it is still full of pus, it might be time to consider spaying her.
I hope she starts to respond. If this does turn into a closed pyometra, she will become sick: not eating, vomiting, etc.
Let me know how she is doing.
I hope you were able to see my answer. How is she doing? Can I help with anything else?
How is your dog doing?
Did the prostaglandins ever help, or did she have to have surgery?
I would like to hear how she is doing!