Welcome to Justanswer! I am Dr. Altman and happy to assist you both today!
Luckily Levetiracetam is a relatively safe agent. Dogs given 1200 mg/kg/day (approximately 20X therapeutic dosage) developed only salivation and vomiting. Human patients given 6000 mg/kg during drug testing developed only drowsiness. Other effects noted in human overdoses (doses not specified) after the drug was released include depressed levels of consciousness, agitation, aggression and respiratory depression.
There were 114 single agent exposures to levetiracetam reported to the ASPCA Animal Poison Control Center (APCC) during 2009-2013. Of the 108 dogs, 13 were symptomatic with lethargy (69%), hyperthermia (15%), recumbency (15%) and vomiting (15%) being the most common clinical signs.
Treatment is basically supportive of clinical signs that are seen; the drug can be removed with hemodialysis. In the circumstance of a significant overdose in animals, contact an animal poison control center for further recommendations.
Your little dog at 10 pounds (4.5 kg) ingested a 250 mg tablet at a dose of 56 mg/kg well below the dose listed above, the normal dose is approximately 20 mg/kg...
You can elect to induce vomiting at 1 tsp per ten pounds of 3% hydrogen peroxide (i.e. 1 tsp for your dog) to remove it from her system and reduce any anxiety you have overnight in monitoring her or you can elect to monitor for any clinical signs listed above for an 8-12 hour period
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