Hi there, I'm Dr. Sara. I'm a licensed veterinarian who works exclusively with dogs and cats. I'm sorry that there's been a delay in answering your question. I suspect that the delay is related to the fact that Ziggy is displaying some very nonspecific signs that we aren't going to be able to really diagnose online.
When I hear about pets who are suddenly unwilling to settle, I consider either pain or anxiety high on my list. The most common cause of pain that is "vague" like this is back pain. Some dogs will act completely out of sorts when their back is sore - especially if it's difficult to lay down. Having said that, though, without doing a physical exam, we really can't localize the potential source of pain or offer much advice on where it came from or how to treat it.
It could also be that he's in the early stages of some other illness - for instance he's nauseous and about to begin vomiting or crampy and about to begin having diarrhea. In these cases, it really is just a "wait and see" on what will happen next.
Sometimes they can also be sensing (hearing, smelling, feeling) something that is causing them great anxiety. I've seen dogs react to all sorts of odd things that you'd never think would frighten them. In these cases we need to observe them closely to see if we can trigger the source of the anxiety.
I've seen plenty of dogs who have discomfort from itching - you did describe that he's been licking in between his toes - if this is bothering him quite a lot, it could also be the cause of his reluctance to settle. How is he doing now? Feel free to reply with an update on his condition and more questions.
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