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My name is***** and I am very sorry to hear that Michele is losing weight. Weight loss in an older dog is unfortunately not a good sign and can be caused by a number of different things. Causes of weight loss include diabetes (which would show high blood sugar on blood work), kidney failure (high kidney enzymes on blood work), liver disease (high liver enzymes on blood work), inflammatory bowel disease (usually you will see vomiting and/or diarrhea), intestinal parasites (highly unlikely), pancreas function problems and lastly cancer. I am very concerned that she may have cancer based on the fact that her blood work was completely normal and her symptoms are getting worse. Urinary incontinence is not a typical symptom for mirtazapine so I don't think that is the cause of the new symptoms.
I would recommend taking her back to your regular veterinarian to discuss x-rays and possibly an abdominal ultrasound to determine exactly why she is losing so much weight so that you can start the best treatments for her.
I am so sorry I don't have good news this evening. I will be thinking about you tonight.
I hope this answer helps you. Feel free to contact me if you have any further questions.
Kansas State University
College of Veterinary Medicine Class of 2001
I am just checking into see how Michele is doing this evening. Feel free to give me an update or ask any more questions.
Also, If you could consider rating our conversation, I would really appreciate it.