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I am sorry to hear you are worried about Trixie. How is she doing now?It would help me to know the ingredients of the medication. I searched under Heartland chewable, but can't find it anywhere. It is Heartland, not Heartgard? Can you check the label and tell me the active ingredients?
An itchy face can indicate an allergic reaction to something, either an ingredient in the medication, or an insect sting or spider bite. Giving Benadryl might help: 1 milligram per pound of her body weight ( 25 mg for a 25 pound dog).
Let me know how she is doing and what else I can answer or help with. Rebecca