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Hi there. Thanks for the question. Let me see if I can help. No...it is NOT safe to use that powder in the eye. Do not apply anything else to the eye. It is good that you rinsed it once but beyond that you do not want to do anything more until you hAve the dog examined by a vet. Your dog likely has either conjunctivitis or a corneal ulcer. These require appropriate medical treatment with eye medication. There is nothing you can use at home. Try to keep your dog from rubbing the eye. And get him in to see a vet soon. I hope this helps. Best of luck.