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Hello. Thanks for the question.
An enlarged heart is most commonly due to a leaking valve in the heart. This leads to poor flow of blood and enlargement of chamber sizes. There is no cure for that leaking valve, other than valve replacement surgery. This has been attempted in dogs, but we're not there yet to do it successfully. That's probably another 10-20 years down the road. For now, we have diuretics (Lasix), ACE Inhibitors (Enalapril) and meds to help the heart function more normally (Pimobendan/ Vetmedin). I usually start my heart failure patients on all 3 right off the bat. This is shown to improve quality of life and life expectancy. Many dogs can be managed for years this way.
I hope this helps, let me know if you have any other questions.