Welcome to JustAnswer! I am a licensed veterinarian and would be glad to help!
If you are referring to a lick granuloma for example or a hygroma (pressure sore) - the way to differentiate this from cancer is with a biopsy.
There is no other way.
Some type of aspirate or biopsy would be needed.
There are actually special protector, sleeves for this.
Called Dog Leggs
That should help with these lesions/
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