How JustAnswer Works:
  • Ask an Expert
    Experts are full of valuable knowledge and are ready to help with any question. Credentials confirmed by a Fortune 500 verification firm.
  • Get a Professional Answer
    Via email, text message, or notification as you wait on our site.
    Ask follow up questions if you need to.
  • 100% Satisfaction Guarantee
    Rate the answer you receive.
Ask Dr Pete Your Own Question
Dr Pete
Dr Pete , Dog Veterinarian
Category: Dog Veterinary
Satisfied Customers: 3009
Experience:  Bachelor of Veterinary Science University of Melbourne
Type Your Dog Veterinary Question Here...
Dr Pete is online now
A new question is answered every 9 seconds

my dog has been prescribed a course of macrolone/prednisolone

Resolved Question:

my dog has been prescribed a course of macrolone/prednisolone - she is drinking profusely and as a result now is almost incontinent - she goes out side to empty her bladder but she is virtually leaking urine - is there anything I can do to stop her and what will happen if I take her off the steroids too soon
Submitted: 6 years ago.
Category: Dog Veterinary
Expert:  Dr Pete replied 6 years ago.

Hi Annie

Can I ask you first

  1. What was the reason she was put on the prednisolone?
  2. Has this problem now resolved?
  3. How long has she been on the medication?
  4. Is the incontinence only when she’s resting/lying down or also when she’s moving around/awake?
  5. What sort of volume is she leaking? How big a patch where she lies after how long?


Customer: replied 6 years ago.

She had a longstanding yeast infection in her ear which I had been told was likely to be ongoing. I had been rinsing out her ear with Malecetic solution as often as possible but it made little or no difference and so I took her to my vet and said I would like her anaesthetised and examined properly. She discovered that the eardrum had been perforated as a result of the "infection"


She put her onto a course of antibiotics (now finished) and approx. 28 days of steroids (prednisolone/macrolone) We saw the Vet again today and I told her that Annie was making puddles everywhere despite my taking her out every half hour or so. She has been on the medication for approx. 8 days - now down to a half tablet (20mg) once a day. She suggested that I cut the dose to 1/4 tablet every other day but so far it has made little or no difference to the incontinence. She is 'leaking' while lying down and basically not huge amounts but enough to wet whatever she is lying on. She has been on the floor with me and I have literally watched the urine dripping out . I rang my emergency vet who suggested I give her Sudafed but as I said before it's p.m. - live out in the country and the Pharmacies are closed. To be honest she is totally unconcerned so I guess it's me that's going nuts. H E L P!!

Expert:  Dr Pete replied 6 years ago.

Thanks for that

First let me assure you that you are correct in that she won’t be too concerned about what is happening. At the most she will be busy cleaning herself up. But of course I understand your concern. Can I also reassure you that this is a common problem and is generally quite reversible.

One of the most common side effects of cortisone is an increased urine output (and therefore thirst). In addition it will cause some degree of relaxation of muscular tone and that can affect the bladder sphincter. So the combination of increased urine flow and a weaker bladder sphincter will often result in incontinence. This side effect is generally temporary but it needs to be said that many dogs affected in this way are marginally incontinent anyway and the medication acts as a trigger. So it may be that her incontinence will reappear at some stage later either intermittently or as more of a chronic issue. It can be treated with medications like Sudafed or more commonly phenylpropanolamine (Proin).

But back to your current concern. Cortisone dosage should always be reduced slowly. Usually this is done by first reducing the actual dose and then by reducing the frequency. That’s what your vet has suggested. Stopping the cortisone too quickly doesn’t allow the adrenal glands to restart their own cortisol (the body’s natural cortisone) production to compensate and can cause problems. So you need to continue with the instructions your vet has given you. Even if you stopped the cortisone abruptly the incontinence would not necessarily suddenly disappear…it can take a few days.

The incontinence almost certainly will clear once the cortisone is completely out of her system. There’s no home remedy to stop it sooner unfortunately. You should contact your vet again once she is available to discuss medication (perhaps Proin) although I feel that if you can manage the problem in the short term she may not need any medication anyway. I normally suggest to people that they place a plastic sheet over the patient’s bedding and use towels over that. Check also that she doesn’t get a urine scald around her genitals. Wash her if necessary. Take her outside as often as possible to reduce the pressure effect.

So…you are not going nuts. You’re simply concerned about her and that’s ok. But it’s my job to reassure you that there is nothing seriously bad going on here.

I hope I’ve helped but please contact me back if I can assist further.

Kindest regards, Peter

Dr Pete, Dog Veterinarian
Category: Dog Veterinary
Satisfied Customers: 3009
Experience: Bachelor of Veterinary Science University of Melbourne
Dr Pete and 4 other Dog Veterinary Specialists are ready to help you
Customer: replied 6 years ago.

Many thanks, XXXXX XXXXX Greyhounds are very cool customers and not much bothers them - it's just the fact that my adopted dogs live inside and on whatever they get to first so maybe some industrial cleaners when the macrolone is finished!! In the meantime it's done the job as far as the ear is concerned but I am mindful that the proin is around and maybe that is the answer if the incontinence continues. I gather when they are speyed this can happen


Thank you again and goodnight



JustAnswer in the News:

Ask-a-doc Web sites: If you've got a quick question, you can try to get an answer from sites that say they have various specialists on hand to give quick answers... seen a spike since October in legal questions from readers about layoffs, unemployment and severance.
Web sites like
...leave nothing to chance.
Traffic on JustAnswer rose 14 percent...and had nearly 400,000 page views in 30 days...inquiries related to stress, high blood pressure, drinking and heart pain jumped 33 percent.
Tory Johnson, GMA Workplace Contributor, discusses work-from-home jobs, such as JustAnswer in which verified Experts answer people’s questions.
I will tell you that...the things you have to go through to be an Expert are quite rigorous.

What Customers are Saying:

  • It was so professional, so personally concerned (as we were) and you answered all of our questions. George and I are so happy that I found "JustAnswer" on my Google search -- you are now in my "Favorites" list! And, yes we do love our kitty - she makes our life complete! Bev & George Boca Raton, FL
< Previous | Next >
  • It was so professional, so personally concerned (as we were) and you answered all of our questions. George and I are so happy that I found "JustAnswer" on my Google search -- you are now in my "Favorites" list! And, yes we do love our kitty - she makes our life complete! Bev & George Boca Raton, FL
  • Wonderful service, prompt, efficient, and accurate. Couldn't have asked for more. I cannot thank you enough for your help. Mary C. Freshfield, Liverpool, UK
  • This expert is wonderful. They truly know what they are talking about, and they actually care about you. They really helped put my nerves at ease. Thank you so much!!!! Alex Los Angeles, CA
  • Thank you for all your help. It is nice to know that this service is here for people like myself, who need answers fast and are not sure who to consult. GP Hesperia, CA
  • I couldn't be more satisfied! This is the site I will always come to when I need a second opinion. Justin Kernersville, NC
  • Just let me say that this encounter has been entirely professional and most helpful. I liked that I could ask additional questions and get answered in a very short turn around. Esther Woodstock, NY
  • Thank you so much for taking your time and knowledge to support my concerns. Not only did you answer my questions, you even took it a step further with replying with more pertinent information I needed to know. Robin Elkton, Maryland

Meet The Experts:

  • Dr. Debbie

    Dr. Debbie

    Dog Veterinarian

    Satisfied Customers:

    Companion animal veterinarian practicing for over 10 years.
< Last | Next >
  • Dr. Debbie's Avatar

    Dr. Debbie

    Dog Veterinarian

    Satisfied Customers:

    Companion animal veterinarian practicing for over 10 years.
  • Dr. Andy's Avatar

    Dr. Andy

    Medical Director

    Satisfied Customers:

    UC Davis graduate, emphasis in dermatology, internal medicine, pain management
  • Dr. Scott's Avatar

    Dr. Scott


    Satisfied Customers:

    15 years of small animal, equine and pocket pet medicine and surgery.
  • Dr. Gary's Avatar

    Dr. Gary

    Dog Veterinarian

    Satisfied Customers:

    DVM, Emergency Veterinarian, BS (Physiology)
  • 's Avatar

    Satisfied Customers:

  • Dr. Bruce's Avatar

    Dr. Bruce


    Satisfied Customers:

    15 years of experience as a small animal veterinarian
  • Dr. Drew's Avatar

    Dr. Drew

    Dog Veterinarian

    Satisfied Customers:

    Small Animal Medicine and Surgery

Related Dog Veterinary Questions