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Okay, then we can try here. I will give instructions. Please give me following info.
1) Which version of Windows you are using ?
2) You said, malware messed group policy settings. Please give details.
Can you please calrify what you mean by "Your organization" ? Is there any organization's name?
Okay, please download following Malware cleaning tools. Then install and Run it. Remove all the infections it find.
Hitman Pro https://malwaretips.com/download-hitman-pro
After scanning with all these tools and removing the infections once again try to start defender and let me know the result.
Yes, please do with the tools I recommended.
Okay, do you have any other Antivirus or firewall program installed on your computer?
If you have another Antivirus program installed on your computer, Defender will not turn ON. If your system time is wrong, defender will not ON. Can you please remove iObit malware fighter and check again? Windows firewall is not a problem.
Okay, then please go to C:\Program Files\Windows Defender\ and right click on MSASCui.exe and select Run as Administrator.
If the same error occurs again, please do the following:
Hold down Windows Logo key and press R key on your keyboard.
You will get open the Run command box.
Type regedit in the run command box and press Enter.
Open HKEY_LOCAL_MACHINE\Software\Policies\Microsoft\Windows Defender in the registry and look for a value DisableAntiSpyware and just delete that value.
Now try to run defender again.