Hi, I'll be happy to help with this
The standard setup splash screen appears to trigger this
but you can install Quake 4 on Vista without any issues
if you go to Start-->Computer and right-click the Quake Install disc and choose Explore
there should be a file called Setup
double-click on that and the installation should launch normally
and you can install, and then run Quake 4
Let me know how that goes....