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If you are getting a Low Disk Space warning it means that you are running out of available space on your hard drive.
If you open start, programs, accessories and then open System Tools you should see a program called Disk Cleanup, Run that and it should help clean up some space on your drive.
Other than that you may need to just go through and remove some files or programs to free up some space on your machine.
Let us know if you need more info.