My name is***** am sorry to hear that you are having this issue.
I will be glad to assist you with this.
have you connected the remote your computer with the usb cable?
In order to set up the remote, you will need to connect your remote to your computer using the USB cable provided and go to www.logitech.com/myharmony.
To begin, connect your remote to your computer using the USB cable provided and goto www.logitech.com/myharmony. Follow the instructions to download the HarmonyRemote Software. After the software installs, start the Harmony Remote Software.When you start the Harmony Remote Software, it checks for updates automatically anddownloads them if necessary.After you install the Harmony Remote Software and gather your device information usingthe Device Worksheet, the setup process guides you through five steps in which youanswer a series of questions about how your entertainment system is set up.1. Creating your user account: The setup walks you through creating a user account onthe Harmony Remote Software. You can also launch a tutorial about how to set up theHarmony 650 from this step by clicking View Tutorial.2. Connecting your Harmony 650 to your computer: The software ensures that your computerand Harmony 650 are communicating with each other.3. Setting up the devices you want to control: The software walks you through entering themanufacturer and model numbers of your entertainment system that you collected usingthe Device Worksheet.4. Setting up Activities for the Harmony 650: The software asks you questions about how yourentertainment system is set up, and then saves the settings.5. Updating the remote: The software transfers the information from your computer to theremote.