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Have you installed the REQUIRED software?
SetPoint Logitech Control Center
Logitech Unifying Software
YOu can get them HERE:
You may also try to RESET the trackball orientation settings
Click the My Mouse tab at the top of the SetPoint (required software) Settings Window.
Click the orientation icon on the left toolbar to display the Orientation Settings screen.
Click the Set Orientation button and roll the trackball forward to align the trackball motion with the pointer motion.
NOTE: You can click the "?" next to Orientation Settings at the top for details.
Click Apply to save your settings and then OK to exit.