how many miles is on the truck?
has any work been done on it lately?
tell me all you can
sense you dont feel the miss....
you may need to just replace the plugs and the wires...
sometimes the plug gap will get wider from heat over time..
also,you need to check the fuel pressure,these must have no less than 55psi at all tikmes,,a weak fuel pump can also cause the 300 code.................from the way you explain your problem,i think the tune up[plugs and wires] will fix the problem...
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the wires and the plugs can do this,,,,,,,also,dont forget to check the fuel pressure,,,,low pressure can also do this