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Hi this is Dr. Hill. Please give me a moment to type my response. Thank you
Depo is a potent steroid and can push some cats that are borderline diabetics into full blown diabetics. It is not common for the steroid to cause major gastrointestinal problems in cats, but it can. I would definitely have Buddy seen today to have some blood work and also anti nausea medication. I would also make sure that if your regular vet is not open today, that you let them know first thing Monday morning. If Buddy continues vomiting then he will become dehydrated. Please ask any follow up questions. You can continue posting on this thread for several days after rating my response. Take care