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Hello, I'm Dr. Deb and will do my best to help you today.
I'm sorry for this concern about Keary; I can just imagine how distressing it is for both him and the other occupants of the car when he excessively vocalizes during the car ride ....having experienced this same problem myself on occasion.
Gravol or Dimenhydrinate can be given to cats although I typically suggest it primarily for motion sickness. However, having said that, anti-histamines often have the side effects of sedation or drowsiness so it may be effective in this situation. The dose would be 1/2 of a 50 mg tablet which can be given every 8 hours.
Most cats tolerate this drug fairly well but GI effects (diarrhea, vomiting, anorexia) have been reported.
I hope this helps. Deb