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I am sorry to hear you are worried about Josie. Thank you for trying to help your mother in law with her cat. My name is Rebecca. I am a veterinarian and will do my best to help.
Has she had a chest Xray to see if she has feline asthma? If not, a chest Xray might be a good idea.
Pet tinic is often used in anemia; is she anemic (low red blood cell count, pale gums). B12 is also used for anemia, and gastrointestinal conditions. 5000 mcg once a day sounds a little high to me, but it is hard to overdose on it. I usually give a cat 250 mcg once a week.
Is she eating well? Any weight loss? How old is Josie?
I hope you were able to see what I sent; I did not hear back from you. How is Josie doing? Please let me know if this was helpful and if you have any more questions.