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This is Dr. KV. It sounds like Roo is quite the handful. One option to consider would be to have a mobile vet come to your house. This may be a much less stressful way to get Roo vaccinated and examined. There is also an oral flea preventative called comfortis that the vet could prescribe for him, which can be mixed into food. That way, you do not need to struggle with him to apply the paradyne.
You're welcome. Yes, it could be a great option for Roo. I usually recommend crushing the tablet in some wet food. Many cats take it without knowing it is there, but it would be something you'd have to test out with him.
Feel free to reach out if I can assist you further,