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Has Frankie had any symptoms after his initial cry/howl and panting? Or does he seem returned to normal?
There are many possible causing for this type of cry but a distress cry is most common. It could be behavioral (something scared him) or it could reflect a physical issue such as pain but in order to isolate where this distress would be coming from will require he show us a bit more symptoms or at least that he continues to not be himself.