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Hello, this is Dr. Jess. I am sorry to hear about your ferret- has he just become very weak and so cannot move? Is he drooling at all?
Any possible trauma? Anything in the house he could have gotten into? Any other health abnormalities recently? Are his gums pink or do they seem pale in color?
So the most common cause of weakness in a ferret is hypoglycemia due to a insulin secreting tumor of the pancreas. Just in case that is the issue here, I would recommend rubbing karo syrup or honey on his gums to try to get some extra sugar into this blood stream.
You feel like his neck looks bent strangely?
Ok. The karo syrup is about the only thing you are going to be able to do for him at home. I would recommend getting him to a vet ASAP. I don't know if you have an emergency one available or not, but if not, then first thing in the morning. There are many different things that can cause leg weakness in ferrets. The insulinoma is the most common (and hypoglycemia can become life threatening- if your ferret becomes more weak/lethargic or has seizures, this is an emeregency), other possiblities include trauma/spinal cord compression, abdominal masses/tumors, enlarged spleen, cardiac issues, and more. To determine which would be causing these would require an exam. Here is an article with a little info on this: http://www.petmd.com/ferret/conditions/neurological/c_ft_paralysis_and_paresis
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