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I'm sorry that your question wasn't answered in a timely manner. I'm not allowed to perform an internet search for you but you can google the keywords: "knee replacement veterinary school cat" and find quite a few schools who have performed total knee replacements on cats. I don't know what "clean, holistic, or organic" means to you. Increased fatty acids - particularly the omega-3 fatty acids such as EPA - are antiinflammatory and of value in arthritic patients. I add fish oil to the diet at a daily dose of 20 mg/lb of the EPA in the fish oil. A human generic fish oil will suffice. Please respond with further questions or concerns if you wish.
Please see here: http://www.hillspet.com/products/pd-feline-jd-feline-mobility-dry.html I have no experience with such an advanced surgery nor am I privy to what a veterinary school hospital would charge for such surgery. Contacting the school you've found online is your best source of information for the prognosis following surgery and your expenses. North Carolina State Veterinary school (please see here: https://news.ncsu.edu/2012/01/feline-first/) was the first in the United States to perform such a surgery on cats.
I'm aware only of the Hill's food I posted above. I've offered up all I have and so I'm going to opt out which will allow other expert to enter the conversation. Please don't leave a rating or respond to me - either of which will dissuade other experts.
I am sorry that you have been waiting for a response. I recently just logged onto the site and noted that your post is still open for other ideas. I am a licensed veterinarian with over 25 years’ experience and would be happy work with you if you are still needing assistance. I do have to agree with the previous expert on the omega three fatty acid, but it is not uncommon that cats will not eat food that has has anything added to it. The Hills j/d diet suggested is an excellent way to get the fish oil (in a significant amount) into him as it is present in the food already along with supplemented antioxidants that can be very beneficial for arthritis pain. Other nutricueticals besides the adequan are other chondroprotective agents given orally. They all work very similarly, but many pain experts feel that the combination of adequan with an oral form seems to have synergistic effects. Dasuquin for cats Another product that shows some promise is Duralactin. Duralactin® is a patented dried milk protein from the milk of hyperimmunized cows. It’s action is to reduce inflammation of osteoarthritis and tissue damage that results because of it. It is available as an oral supplement. Here is a link with more information. Duralactin Two other therapies that help many pets with pain is acupuncture and laser therapy. I would search for vets in your area that may be offering these forms of treatment. If you haven't used any pharmaceuticals, and you are to the point of discussing amputation, I would certainly consider those first. We are somewhat limited in our choices for pain control in cats, but gabapentin and tramadol are options that if used along with other pain control modalities as described above, may offer a limb sparing option. I hope this is helpful. Please let me know if you have ANY other questions. My goal is to give you 100% satisfaction and if you are not yet satisfied, please reply so I can clarify for you. Dr Z