Hello I am Dr. Joey. Thanks for trusting me to help you and your pet today. I am a licensed veterinarian with over 15 years of experience. I look forward to working with you.
This does sound concerning for Sophie. The inappropriate urination could be due to a variety of issues, but the top two would be she has a primary urinary tract problem such as infection or bladder stones or crystals in her urine. The other issue could be that she has something that is inspiring her to drink more and then secondarily need to urinate all the time. Sounds like we have ruled out CKD and hyperthyroidism
which leaves a different medical problem such as liver issue or cancer. I assume her lab work testing her liver values. Tehrefore, the most common cause of marked weight loss in spite of a decent appetite and increased urinations is a tumor/cancer.
To diagnose this would require further testing,g probably starting with an X-ray and urinalysis. If this is not possible, then you need to discuss with your vet doing a therapeutic trial which means treat her with medication for a potential urinary tract infection to see if this improves the situation; this is an antibiotic which is prescription. There is nothing over-the-counter to help treat this.
The use of a good quality food
is excellent because we do want to inspire her to continue to eat. You may need to restrict access to the area of the house she is urinating. You need to also cleanse the areas she urinated with a good enzymatic cleanser to get the smell out.
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