Different contributor here. The original contributor has decided to terminate their interaction with you (I don't know why). I am a member of the State Bar of California, the U.S. District Court for the Central District of California (LA/OC metro and surrounding counties) and the California and National Associations of Realtors. I have worked in the intellectual property "biz" for decades. Please permit me to assist.
In my opinion, "[subject] Guide" is an extremely descriptive trademark, assuming that you are using the marks to describe medical products or services -- because you are simply describing the product or service being offered, and it requires no imagination on the part of an ordinary consumer to understand the connection between the trademark and the product/service.
However, since I don't actually know what you're trying to market, my assumption may be incorrect. At a minimum, I would want to concatenate the terms (e.g., "MedGuide", etc.). But, even in this circumstance, unless (by example) the product is some sort of equipment that is used to direct a medical device to a particular body organ, it still doesn't take much imagination to (also by example), connect a "Guide" with a website that "guides" users to various medical diagnoses. I hope you see the difficulty here.
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