Thanks for using J/A / Pearl
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My answer may not be to your liking, but is a correct & honest answer.
Many times the only fix will be by Dealer or Shop, so please do not hold that against me.

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just got a new keyless entry remote for my 2000 acura TL, can you try to help me how to set it up properly.

Here is Acura procedures

click link below

PROGRAM TRANSMITTER

If you need further, please ask "before" you Rate my Answer...............