A single cylinder misfire is not likely to cause the engine to stop running on you, but there are short and long term negative effects of driving with an engine misfire:
Thank you for your reply. This vehicle was involved in a rear end collision several days ago. Although the engine is not in the rear, could the shockwave from the impact caused this problem? Given the damage to the vehicle( the insurance company wants to total the vehicle) and the cylinder misfire that caused the check engine light to come on is it worth keeping the vehicle.
While theoretically possible, it is extrremely unlikely that a collision to the rear end would be responsible for an engine misfire.
Honestly, no one online can determine whether your vehicle is worth keeping or not, just based upon your description of damage.
An engine misfire can be something as simple as a faulty plug, faulty injector, or faulty plug wire. You dont get rid of a car for an engine misfire.
If the insurance companies wants to total it, then you have to decide whether it is repairable or not if you decide to keep it. There could be frame damage that cannot be straightened adequately, or other damage that is not feasible to repair. You may be better off letting them total it